A BIOS bug in firmware for a particular PC model leaves the Platform authorization value empty. This can be used to permanently brick the TPM in multiple ways, as well as to non-permanently DoS the system.
Exploitability
AV:NAC:LPR:NUI:NScope
S:UImpact
C:NI:NA:H7.5/CVSS:3.1/AV:N/AC:L/PR:N/UI:N/S:U/C:N/I:N/A:H