A HTTP/2 implementation built using any version of the Python HPACK library between v1.0.0 and v2.2.0 could be targeted for a denial of service attack, specifically a so-called "HPACK Bomb" attack. This attack occurs when an attacker inserts a header field that is exactly the size of the HPACK dynamic header table into the dynamic header table. The attacker can then send a header block that is simply repeated requests to expand that field in the dynamic table. This can lead to a gigantic compression ratio of 4,096 or better, meaning that 16kB of data can decompress to 64MB of data on the target machine.
Exploitability
AV:NAC:LPR:NUI:NScope
S:UImpact
C:NI:NA:H7.5/CVSS:3.0/AV:N/AC:L/PR:N/UI:N/S:U/C:N/I:N/A:H